3D‑Printed Insulin-Producing Pancreatic Islet Cells Show Promise for Type 1 Diabetes

Published 2025-07-09

Researchers showcased a groundbreaking advance at the International Transplant Congress: 3D-printed pancreatic islet cells using bio-ink composed of decellularized human pancreatic tissue and alginate. In vitro studies demonstrated these constructs remained viable and responsive to glucose over a three-week period—suggesting a more controlled, implantable alternative to traditional islet transplants. The subcutaneous placement method may reduce procedural risks, and ongoing animal testing is evaluating long-term engraftment and insulin regulation.

In parallel, scientists in the Netherlands have developed a novel DdCBE gene-editing tool targeting mitochondrial DNA mutations—a domain previously unreachable by CRISPR. Delivered via lipid nanoparticles akin to mRNA vaccines, early lab results show targeted correction of mitochondrial defects, paving the way for future therapeutic strategies in mitochondrial diseases