Induced Pluripotent Stem Cell Derived GABAergic Neurons for Neuropathic Pain

Published 2020-02-04

Researchers from the University of Sidney's School of Life and Envirnonmental Sciences, led by Professor Greg Neely performed the first successful preclinical trial using GABAergic Neurons as a therapy for neuropathic pain in mice. GABAergic Neurons were generated from differentiation of induced Pluripotent Stem Cells and injected into the spinal cord of mice suffering from induced neuropathic pain. Subsequent to the treatment, lasting pain relief without side effects was noted. Next steps are extensive safety study in rodents and pigs, prior to human clinical trials. The findings were published in the February 2020 issue of the journal Pain.